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In February 2015, the UK became the first country to approve laws allowing for the creation of so called “three-parent babies”. Despite the UK being first in line to approve the legislation, there has been a three year delay before doctors have now been granted permission by the Human Fertilisation and Embryology Authority (HFEA) to use the procedure on two women in the UK.
The first “three-parent baby” born as a result of mitochondrial transfer was born in a Mexican fertility centre in 2016.
Legislation was brought into force in the UK in October 2015 to prevent fatal genetic disorders known as mitochondrial DNA disease being passed from mother to child. Faulty mitochondria can only be passed to a child by its mother. It is possible for those who have inherited defective mitochondria to simply be carriers experiencing no symptoms, however, those less fortunate, (reported to be around 1 in 6,500 children) will develop serious symptoms which can include, brain disease such as epilepsy, heart problems, diabetes and stroke-like episodes and can lead to death during childhood.
Mitochondria exist in every cell of our body. They provide the power or energy which enables the cell to fulfil its function within the body. If the mitochondria in the cell are defective or faulty, the cell will not be able to perform its function as effectively as it should. The nucleus of a cell contains 99.8% of our DNA (nuclear DNA), while the mitochondria in the cell are said to contain only a very small amount of genetic material, between 0.2 and 0.1%.
Whilst this potentially life-giving and life-saving science is fully backed by the UK government, there have been wider concerns about the risks associated with this type of procedure. The birth of the first child using mitochondrial donation in Mexico occurred in an unregulated environment which sparked concern. The approval of the use of mitochondrial donation therapy by the HFEA has meant that the instances of mitochondrial donation therapy in the UK will be properly regulated and controlled.
Critics of the therapy have questioned whether a child born as a result of mitochondrial donation will truly have three parents as the headlines suggest. Some parents may question the status of the donor given that between 0.1% and 0.2% of the child’s genetic material will come from the mitochondrial donor. The wording of the guidance around the legislation is clear that the donor will be seen as a donor and not a prospective parent and they will not have any legal status as a parent of the child. Under English law, the legal mother of the child on birth is always the gestational mother, i.e. the person who has carried and gives birth to the child.
In terms of genetics, research demonstrates that almost the entirety (99.9% or 99.8%) of the child’s genetic material will come from the prospective parent who provides the nuclear DNA. It is understood that mitochondrial DNA (provided by the donor) does not have any impact on the physical characteristics or personality traits of the child, it merely provides the vital, life-saving mitochondria which enables the child’s cells to function normally.
Parents may also be concerned about the involvement of a donor in the donation therapy process and following the birth. The Human Fertilisation and Embryology (Mitochondrial Donation) Regulations 2015 confirm that the egg or embryo resulting from a mitochondrial donation is not to be treated as an egg or embryo belonging to the donor. Moreover, a mitochondrial donor who is a donor in a surrogacy arrangement will not be able to apply for a parental order in respect of that child on the basis of their mitochondrial donation alone.
The Regulations also confirm that a child born as a result of mitochondrial donation will not have access to donor information, save for limited non-identifying information in certain circumstances.
Although many critics have heralded this development as the beginning of designer babies, it is clear that the legislation and regulations are aimed at the important work of preventing fatal genetic disorders being passed from mother to child and ensuring that this takes place in a safe, licensed and tightly regulated manner.
Should you have any questions relating to international surrogacy and the Parental Order process, please contact Olivia Stiles or a member of the family team.
You may also be interested in reading more about international surrogacy and the position in the UK HERE. Further information can also be found on our Frequently Asked Questions page about surrogacy and our previous blogs.
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